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Phospho-Connexin 43 (Ser368) Rabbit anti-Bovine, Canine, Chicken, Guinea Pig, Human, Mouse, Rat, Zebrafish, Polyclonal, Invitrogen™ Non-distribution product as customer accommodation. Available on GSA/VA Contract for Federal Government customers only.

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen 483000

Catalog No. 48-300-0


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Description

Description

Connexin 43 (Cx43) is a member of the gap junction protein family. Connexins assemble as a hexamer and are transported to the plasma membrane to create a hemichannel that can associate with hemichannels on nearby cells to create cell-to-cell channels. Clusters of these channels assemble to make gap junctions. Gap junction communication is important in development and regulation of cell growth. Phosphorylation of Cx43 is important in regulating assembly and function of gap junctions. Ser368 of Cx43 is phosphorylated by protein kinase C (PKC) after activation by phorbol esters, which decreases cell-to-cell communication. Src can interact with and phosphorylate Cx43 to alter gap junction communication. GFAP are membrane-spanning proteins that facilitate the transfer of ions and small molecules between cells. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Connexin 43 is the major protein of gap junctions in the heart, and gap junctions are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. Connexin 43 is also targeted by several protein kinases that regulate myocardial cell-cell coupling. A related intron-less connexin 43 pseudogene, GJA1P, has been mapped to chromosome 5. Mutations in the GFAP gene cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy, oculodentodigital dysplasia and heart malformations. Alternatively spliced transcript variants of GFAP have been found.

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Specifications

Specifications

Phospho-Connexin 43 (Ser368)
Polyclonal
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
P18246, Q6S9C0, P14154, P17302, P23242, P08050, O57474
CX43, CXA1, CXN-43, Connexin 43, GJA1, Gap junction 43 kDa heart protein, Gap junction alpha-1 protein
Rabbit
IgG
100 μL
Store at -20°C
Primary
100379273, 14609, 24392, 2697, 281193, 30236, 395278, 403418
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
GJA1
Liquid
cx43, GJA1
Phosphopeptide corresponding to amino acid residues surrounding the phosphoserine 368 of rat connexin 43
Affinity chromatography
RUO
Antibody
Polyclonal
Bovine, Canine, Chicken, Guinea Pig, Human, Mouse, Rat, Zebrafish
Documents
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