Phospho-Cortactin (Tyr421) Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen 44854G
DescriptionCortactin (Cttn) is a ubiquitous actin-binding protein that was originally identified as a substrate for Src. It contributes to the organization of the actin cytoskeleton and cell shape. Cortactin also plays a role in the formation of lamellipodia and cell migration. It is accumulated in peripheral, actin-enriched structures of cells suggesting that cortactin facilitates actin network formation. Cortactin has four major domains of interest the N-terminal acidic (NTA) and tandem repeats domains and the C-terminal proline-rich and SH3 Domains. NTA associates with the Arp2/3 and WASP complex at F-actin branches. Cortactin is involved in promoting cell motility and invasion, including a critical role in invadopodia, actin rich-subcellular protrusions associated with degradation of the ECM by cancer cells. Cortactin is phosphorylated by src family kinases at Y421, Y466, and Y482 and S405 and S418 that are phosphorylated by Erk family kinases.
|Dulbecco′s PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide; pH 7.3|
|1110020L01Rik, Amplaxin, cortactin, CTTN, EMS1, ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate), FLJ34459, Oncogene EMS1, Src substrate cortactin, SRC8|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of mouse cortactin that contains tyrosine 421.|
|Antigen affinity chromatography|
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