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Phospho-CREB (Ser133) Rabbit anti-Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA14619

Catalog No. PA14619


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Description

Description

This antibody is predicted to react with bovine, canine, chicken, human, mouse, non-human primate, rat, sheep, Xenopus and zebrafish based on 100% sequence homology. This antibody is specific for the ~45 kDa CREB phosphorylated at Ser133 in Western blots of rat brain lysates. Immunolabeling can be blocked by lambda-phosphatase treatment.

CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation of CREB occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB is involved in different cellular processes including the synchronization of circadian rhythmicity, differentiation of adipose cells, and learning and memory. In humans, the gene is located on the q arm of chromosome 2. Diseases associated with CREB dysfunction include Alzheimer’s Disease, histiocytoma and soft tissue melanoma.
Specifications

Specifications

Phospho-CREB (Ser133)
Polyclonal
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
P15337
phospho-cyclic AMP response element binding protein (Ser133)
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
81646
Immunohistochemistry, Western Blot
Unconjugated
Creb1
Liquid
CREB1
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser133 of rat CREB1 conjugated to KLH
Affinity chromatography
RUO
Antibody
Polyclonal
Rat
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