Phospho-Dynamin 1 (Ser778) Sheep anti-Rat, Polyclonal, Invitrogen
Sheep Polyclonal Antibody
Manufacturer: Invitrogen PA14621
This antibody is predicted to react with bovine, canine, chicken, human and mouse based on 100% sequence homology. This antibody is specific for the ~95 kDa Dynamin protein phosphorylated at Ser778 in Western blots of rat brain lysates.Dynamin is a member of a group of nerve terminal proteins called dephosphins that regulate synaptic vesicle endocytosis Cousin et al., 2001; Graham et al., 2002; Tsuboi et al., 2002). Cyclin dependent protein kinase 5 phosphorylates dynamin at Ser774 and Ser778 that are the phosphorylation sites on dynamin phosphorylated in vivo (Tan et al., 2003). Phosphorylation of these sites on dynamin is thought to play a key role in synaptic vesicle trafficking.
|Phospho-Dynamin 1 (Ser778)|
|0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5|
|DNM, DNM1, Dynamin1, Neuronal dynamin|
|-20° C, Avoid Freeze/Thaw Cycles|
|Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser778 of rat DNM1 conjugated to KLH|
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