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Phospho-EphB2 (Tyr298) Rabbit anti-Chicken, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA14622

Catalog No. PA14622

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This antibody is predicted to react with bovine, canine, human, mouse, non-human primate, Xenopus and zebrafish based on 100% sequence homology. This antibody is specific for the ~46 kDa EphrinB protein phosphorylated at Tyr298. Immunolabeling can be blocked by lambda-phosphatase treatment.

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB4 binds to ephrin-B2 and plays an essential role in vascular development.


Phospho-EphB2 (Tyr298)
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
EFL6, EFNB3, EPH related receptor transmembrane ligand ELK L3, EPH related receptor tyrosine kinase ligand 8, Ephrin B3, EPLG8, LERK8
100 μL
-20° C, Avoid Freeze/Thaw Cycles
313633, 396513
Western Blot
Synthetic phospho-peptide corresponding to amino acid residues surrounding Tyr298 of chicken EPHB2 conjugated to KLH
Affinity chromatography
Chicken, Rat
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