Phospho-EphB2 (Tyr317) Rabbit anti-Chicken, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA14623
This antibody is predicted to react with bovine, human, mouse, Xenopus and zebrafish based on 100% sequence homology. This antibody is specific for the ~46 Dak EphrinB protein phosphorylated at Tyr317. Immunolabeling can be blocked by lambda-phosphatase treatment.Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB4 binds to ephrin-B2 and plays an essential role in vascular development.
|0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5|
|EFL6, EFNB3, EPH related receptor transmembrane ligand ELK L3, EPH related receptor tyrosine kinase ligand 8, Ephrin B3, EPLG8, LERK8|
|-20° C, Avoid Freeze/Thaw Cycles|
|Synthetic phospho-peptide corresponding to amino acid residues surrounding Tyr317 of chicken EPHB2 conjugated to KLH|
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