Phospho-GATA4 (Ser105), Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA122003
GATA 4 is a 46kDa member of the GATA family of zinc finger-containing transcription factors that is involved in the development of cardiac hypertrophy and remodeling, and plays a critical role in regulating basal and agonist or stress-induced gene expression in cardiac and smooth muscle cell types. GATA 4 contains a conserved MAPK phosphorylation site at serine 105 within the transcriptional activation domain. Serine 105 of GATA 4 is phosphorylated in response to agonist stimulation through MEK 1-ERK 1 / 2, and weakly through JNK or p38 MAPKs.PA1-22003 detects Phospho-GATA4 (pSer105) in Mouse samples. Expected to cross react with chicken, human and rat due to sequence homology (100% identity with immunogen).PA1-22003 has been successfully used in Western Blot procedures, where a band of 46kDa is predicted to be detected. Positive control: Phenylephrine-stimulated rat cardiomyocytes, transfected with mouse GATA4PA1-22003 immunogen corresponds to Synthetic peptide (Human) derived from a region of GATA 4 that contains serine 105.
|Synthetic peptide (Human) derived from a region of GATA 4 that contains serine 105.|
|Antigen affinity chromatography|
|Human, Murine, Rat|
|PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.3|
|P43694, Q08369, P46152|
|Store at -80°C, Avoid Freeze/Thaw Cycles|
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