Phospho-HDAC7 (Ser448) Rabbit anti-Bovine, Canine, Equine, Human, Non-human primate, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523384
Suggested positive control: recombit fusion protein lysate.Histone deacetylase 7 is a thymus-specific, intracellular transcription factor belonging to the class IIa histone deacetylase family. Reports suggest that dephosphorylation and nuclear localization of HDAC-7 is promoted by Myosin phosphatase, thus regulating the repression of Nur77 and inhibition of apoptosis in CD4+CD8+ double-positive thymocytes. HDAC-7 plays a specific role in maintaining vascular integrity by repressing the expression of matrix metalloproteinase (MMP) 10. It promotes repression mediated by transcriptional corepressor NCOR2 and is an efficient corepressor of the androgen receptor (AR). It is also responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).
|Synthetic peptide (443 CLSRAQbSPAA 452) of Phospho-HDAC-7 pSer448 protein.|
|Antigen affinity chromatography|
|Bovine, Canine, Equine, Human, Non-human Primate, Rat|
|PBS with 0.05% BSA and 0.05% sodium azide|
|HD7A, HDAC7A, HD7, histone deacetylase 7A|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|100050617, 486589, 509843, 51564, 84582|
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