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Phospho-HDAC7 (Ser448) Rabbit anti-Bovine, Canine, Equine, Human, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523384

Catalog No. PIPA523384


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Description

Description

Suggested positive control: recombit fusion protein lysate.

Histone deacetylase 7 is a thymus-specific, intracellular transcription factor belonging to the class IIa histone deacetylase family. Reports suggest that dephosphorylation and nuclear localization of HDAC-7 is promoted by Myosin phosphatase, thus regulating the repression of Nur77 and inhibition of apoptosis in CD4+CD8+ double-positive thymocytes. HDAC-7 plays a specific role in maintaining vascular integrity by repressing the expression of matrix metalloproteinase (MMP) 10. It promotes repression mediated by transcriptional corepressor NCOR2 and is an efficient corepressor of the androgen receptor (AR). It is also responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).
Specifications

Specifications

Phospho-HDAC7 (Ser448)
Polyclonal
Unconjugated
HDAC7
Liquid
HDAC7
Synthetic peptide (443 CLSRAQbSPAA 452) of Phospho-HDAC-7 pSer448 protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Bovine, Canine, Equine, Human, Non-human Primate, Rat
Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q8WUI4, Q99P96
HD7A, HDAC7A, HD7, histone deacetylase 7A
Rabbit
IgG
50 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
100050617, 486589, 509843, 51564, 84582
Documents
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