Phospho-ErbB2 (HER-2) (Tyr1248) Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen 44904G
DescriptionErbB2 (also known as Her2 or neu) is a 185 kDa transmembrane receptor tyrosine kinase from the EGFR family that acts to regulate a variety of biological responses including cell growth, differentiation, and tissue development. Ligand binding to the extracellular domain, or overexpression of the receptor leads to phosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Overexpression or abnormal activation of ErbB2 has been found in a variety of tumors including brain, breast, lung and skin cancer. Autophosphorylation of tyrosine 1139 on ErbB2 allows binding of Grb2 and the Src SH2 domain, which allows activation of the Ras, Raf, ERK1&2 and JAK/STAT signaling pathways, respectively.
|Phospho-ErbB2 (HER-2) (Tyr1248)|
|Dulbecco′s PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide; pH 7.3|
|Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, CD340, MLN19, NEU, NGL, c-erb B2/neu protein, herstatin|
|The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human ErbB-2 that contains tyrosine 1248. The sequence is conserved in rat, hamster and dog.|
|Antigen affinity chromatography|
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