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Phospho-Huntingtin (Ser434) Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Catalog No. PIPA1088
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Quantity:
100 μL
Catalog No. Quantity
PIPA1088 100 μL
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Catalog No. PIPA1088

Supplier: Thermo Scientific PA1088

Description

Rabbit Polyclonal Antibody

PA1-090 detects ezrin-radixin-moesin (ERM) binding phosphoprotein of 50 kDa (EBP50) from mouse tissues, human T84 and Calu3 cells as well as recombit human protein. PA1-090 has been successfully used in Western blot, Immunohistochemistry, immunofluoresce

Huntingtin is a disease gene linked to Huntington′s disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predomitly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington′s disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-Huntingtin (Ser434)
Applications Immunofluorescence, Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Gene HTT
Gene Accession No. P42858, P42859
Gene Alias Htt, Huntingtin, HD, IT15
Gene Symbols HTT
Host Species Rabbit
Immunogen Synthetic phosphopeptide conjugated to KLH corresponding to GGSSC(pS)PVLSRK (427-438) of Human HTT
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15194, 3064
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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