Phospho-IFNAR1 (Ser535, Ser539) Rabbit anti-Human, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA14627
This antibody is predicted to react with bovine, canine, mouse, non-human primate and sheep based on 100% sequence homology. It is specific for IFNAR1 protein phosphorylated at Ser535,539 in Western blots of human brain extracts.Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system (Biron,2001; Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon-& Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003).
|Phospho-IFNAR1 (Ser535, Ser539)|
|0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5|
|AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry, Western Blot|
|Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser535/539 of human IFNAR1 conjugated to KLH|
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