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Phospho-IFNAR1 (Ser535, Ser539) Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA14627

Catalog No. PA14627


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Description

Description

This antibody is predicted to react with bovine, canine, mouse, non-human primate and sheep based on 100% sequence homology. It is specific for IFNAR1 protein phosphorylated at Ser535,539 in Western blots of human brain extracts.

Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system (Biron,2001; Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon-& Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003).
Specifications

Specifications

Phospho-IFNAR1 (Ser535, Ser539)
Polyclonal
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
P17181
AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
288264, 3454
Immunohistochemistry, Western Blot
Unconjugated
IFNAR1
Liquid
IFNAR1
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser535/539 of human IFNAR1 conjugated to KLH
Affinity chromatography
RUO
Antibody
Polyclonal
Human, Rat
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