Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Phospho-INSR (Tyr1185) Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA512983

Catalog No. PIPA512983


Add to cart

Description

Description

This antibody is predicted to react with bovine, canine, mouse, rat and Xenopus based on sequence homology.

INSR (insulin receptor, IR) is a heterodimeric protein complex that has an intracellular beta subunit and an extracellular alpha subunit, which is disulfide- linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intracellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are the cause of various insulin resistance syndromes and IGF-1R defects may also cause some forms of growth retardation.
Specifications

Specifications

Phospho-INSR (Tyr1185)
Polyclonal
PBS with 0.09% sodium azide
P06213
Insulin receptor [Precursor]; IR; CD220 antigen; INSR
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
3643
Dot Blot
Unconjugated
INSR
Liquid
INSR
KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1185 of human INSR
Antigen Affinity Chromatography, Protein A
RUO
Antibody
Polyclonal
Human
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit