anti-Phospho-JAK2 pTyr221 Polyclonal, Thermo Scientific™ Non-distribution product as customer accommodation. Available on GSA/VA Contract for Federal Government customers only.

Phospho-JAK2 pTyr221 Polyclonal Ab PA5-35832 from Thermo Scientific™ specifically detects Phospho-JAK2 pTyr221 in Hu, Ms and Rt samples, and it is validated for WB

Manufacturer: Invitrogen A14017

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Catalog No. A14017

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    Specifications

    Antigen Phospho-Jak2 pTyr221
    Conjugate Unlabeled
    Cross Reactivity Human,Mouse
    Format Purified
    Formulation 100μL of purified antibody in 0.01M HEPES with 100μg/ml BSA, 50% glycerol, 0.15M NaCl, no preservative; pH 7.5.
    Gene Accession No. O60674, Q62120
    Host Species Rabbit
    Immunogen Synthetic phosphopeptide corresponding to residues surrounding Tyr221 of human Jak2 protein.
    Isotype IgG
    Storage Requirements Store at -20°C
    Primary or Secondary Primary
    Monoclonal or Polyclonal Polyclonal
    Gene ID (Entrez) 16452, 3717

    Phospho-JAK2 pTyr221 Polyclonal Ab PA5-35832 from Thermo Scientific™ specifically detects Phospho-JAK2 pTyr221 in Hu, Ms and Rt samples, and it is validated for WB

    Janus Activating Kinase 2 (JAK2) is one of a number of related tyrosine kinases involved in cytoplasmic signal transduction. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine residues. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. However, active JAK1 may be required for complex responses. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex.
    Host Species: Rabbit
    Cross Reactivity: Human, Mouse
    Isotype: IgG
    Immunogen: Synthetic phosphopeptide corresponding to residues surrounding Tyr221 of human Jak2 protein.
    Formulation: 100µL purified antibody in 0.01M HEPES with 100�g/ml BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
    Synonyms: EC 2.7.10.2, JAK-2, JAK2, Janus kinase 2, kinase Jak2
    Uniprot Accession: O60674, Q62120
    Entrez GeneID: 16452, 3717
    Gene Symbol: JAK2
    This product detects Phospho-Jak2 pTyr221 in Human and Mouse samples. This product has been successfully used in Western Blot procedures. The immunogen is Synthetic phosphopeptide corresponding to residues surrounding Tyr221 of human Jak2 protein..

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