Phospho-JNK1/JNK2 (Thr183, Tyr185) Rabbit anti-Human, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA19593
PA1-9593 detects Phospho-JNK/SAPK in human, mouse, chicken and rat samples. PA1-9593 has been successfully used in Western blot, immunohistochemistry, and immunocytochemistry procedures. By Western blot, PA1-9593 detects a 46 kDa and 54 kDa protein representing Phospho-JNK/SAPK. PA1-9593 immunogen is a phosphorylated peptide (pT183-P-pY185) based on human JNK.The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
|Phospho-JNK1/JNK2 (Thr183, Tyr185)|
|Phosphorylated peptide (pT183-P-pY185) based on human JNK|
|Immunocytochemistry, Immunohistochemistry, Western Blot|
|PBS with no preservative|
|P45983, P49186, P49185, P45984|
|C-jun kinase, JNK 55, MAPK, Mitogen activated protein kinase, SAPK, PRKM , Protein Kinase Mitogen Activated, SAPK 1, Stress activated protein kinase J, Phospho-JNK|
|-20° C, Avoid Freeze/Thaw Cycles|
|116554, 50658, 5601, 5599|
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