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Phospho-LC3B (Thr12) Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA512959

Catalog No. PIPA512959


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Description

Description

This antibody is predicted to react with bovine based on sequence homology.

LC3B (Autophagy Marker Light Chain 3B, MAP1A/MAP1B LC3 B) in humans, is encoded by the gene MAP1LC3B (Microtubule-associated proteins 1A/1B light chain 3B). LC3B is associated with microtubule assembly and important is in neurogenesis. Recent studies indicate that LC3B plays a vital role in autophagy, a process that involves the bulk degradation of cytoplasmic component. Three human LC3 isoforms undergo post-translational modifications during autophagy. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). LC3B is a microtubule-associated protein that mediate the physical interactions between microtubules and components of the cytoskeleton. LC3B may play a role in processes involving cancer, aging, metabolic and neurodegenerative disorders and cardiovascular/pulmonary diseases.
Specifications

Specifications

Phospho-LC3B (Thr12)
Polyclonal
Unconjugated
MAP1LC3B
Liquid
MAP1LC3B
KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T12 of human LC3B
Antigen Affinity Chromatography, Protein A
RUO
Antibody
Polyclonal
Human
Dot Blot
0.35 mg/mL
PBS with 0.09% sodium azide
Q9GZQ8
Microtubule-associated proteins 1A/1B light chain 3B [Precursor]; MAP1A/MAP1B LC3 B; MAP1A/1B light chain 3 B; MAP1 light chain 3-like protein 2; Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1LC3B; MAP1ALC3
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
81631
Documents
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