Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Phospho-ERK5 (Thr218), Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA126728

Catalog No. PA126728

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.

PA1-26728 detects ERK5 (phospho T218) from human samples. PA1-26728 is expected to cross react with mouse (100% conserved) due to sequence homology. PA1-26728 shows some cross-reactivity with ERK1 and 2 (44 and 42 kDa, respectively)PA1-26728 has been successfully used in Immunohistochemistry (frozen), and Western blot procedures. Predicted molecular weight is 88 kDa.The PA1-26728 immunogen is a synthetic phosphopeptide corresponding to a portion of human ERK5 containing threonine 218 and tyrosine 220.Store at 4ºc short term. For extended storage, aliquiot and store at -20ºC or below. Avoid freeze/thaw cycles.
Specifications

Specifications

Phospho-ERK5/MAPK7 pThr218
Polyclonal
Unconjugated
MAPK7
Purified
MAPK7
Synthetic phosphopeptide corresponding to a portion of human ERK5 containing threonine 218 and tyrosine 220.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Murine
Immunohistochemistry (Frozen), Western Blot
1mg/mL
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide; pH 7.3
Q13164, Q9WVS8
BMK1, ERK4, ERK5, PRKM7
Rabbit
IgG
50μL
avoiding freeze/thaw cycles.
Primary
5598
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit