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Phospho-MARCKS (Ser152, Ser156) Rabbit anti-Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA14629

Catalog No. PA14629


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Description

Description

This antibody is predicted to react with bovine, chicken, human, mouse, Xenopus and zebrafish based on 100% sequence homology. This antibody is specific for the ~87 kDa MARCKS protein phosphorylated at Ser152 and Ser156 in Western blots of rat brain homogenates. Immunolabeling is blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide.

Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) is a major substrate for phosphorylation by Protein Kinase C (PKC) (Ouimet et al., 1990). The phosphorylation of Ser152/156 can be used as a measure of PKC activation although these sites are also phosphorylated by PRK1 (Palmer et al., 1996). MARCKS is a member of a family of calmodulin binding protein and phosphorylation of Ser152/156 modulates the binding of MARCKS to calmodulin (Verghese et al., 1994).
Specifications

Specifications

Phospho-MARCKS (Ser152, Ser156)
Polyclonal
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
P30009
phospho-Myristoylated Alanine-Rich C Kinase Substrate (Ser152,156)
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
25603
Western Blot
Unconjugated
Marcks
Liquid
MARCKS
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser152/156 of rat MARCKS conjugated to KLH
Affinity chromatography
RUO
Antibody
Polyclonal
Rat
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