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Phospho-MECP2 (Ser80) Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA513024

Catalog No. PIPA513024


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Description

Description

This antibody is predicted to react with mouse, non-human primate and rat based on sequence homology.

MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3 and MBD4) that have a methyl-CpG binding domain. MECP2 is capable of binding specifically to methylated DNA. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. MECP2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
Specifications

Specifications

Phospho-MECP2 (Ser80)
Polyclonal
PBS with 0.09% sodium azide
P51608
Methyl-CpG-binding protein 2; MeCP-2 protein; MeCP2; MECP2
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
4204
Dot Blot
Unconjugated
MECP2
Liquid
MECP2
KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S80 of human MeCP2
Antigen Affinity Chromatography, Protein A
RUO
Antibody
Polyclonal
Human
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