Phospho-NIPA (Ser354) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA538782

Catalog No. PIPA538782

Description

Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.

Specifications

• Antigen: Phospho-NIPA (Ser354)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZC3HC1
• Gene Alias: 1110054L24Rik, NIPA, hNIPA, hematopoietic stem/progenitor cell protein 216, nuclear interacting partner of anaplastic lymphoma kinase (ALK), nuclear interaction partner of ALK, nuclear-interacting partner of ALK, nuclear-interacting partner of anaplastic lymphoma kinase, zinc finge
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 232679, 296957, 51530
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q86WB0, Q80YV2
• Gene Symbols: ZC3HC1
• Immunogen: A synthetic phosphopeptide derived from human NIPA around the phosphorylation site of Ser354 (T-R-SP-W-D)
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Non-human Primate, Rat
• Product Type: Antibody
• Isotype: IgG