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Phospho-NMDAR2B (Tyr1252) Rabbit anti-Bovine, Canine, Chicken, Human, Mouse, Rat, Zebrafish, Polyclonal, Invitrogen™ Non-distribution product as customer accommodation. Available on GSA/VA Contract for Federal Government customers only.

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen 485200

Catalog No. 48-520-0


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Description

Description

NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors (NMDAR) have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDAR play a role in neuronal development and has been implicated in several disorders of the central nervous system including Alzheimer’s Disease, epilepsy and ischemic neuronal cell death. Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity. NMDR2B is a heterotrimer comprised of seven enetically encoded and differentially expressed subunits that include NR1, NR2 and NR3. Diseases associated with the dysfunction of NMDAR2B include epileptic encephalopathy, autosomal domit 6-related mental retardation.

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Specifications

Specifications

Phospho-NMDAR2B (Tyr1252)
Polyclonal
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Q5R1P3, Q13224, Q01097, Q00960
Glutamate [NMDA] receptor subunit epsilon 2 precursor, GRIN2B, hNR3, N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 3, NMDE2, NME2, NR2B, NR3
Rabbit
IgG
100 μL
-20°C
Primary
14812, 24410, 2904, 417965, 494009, 537804
Western Blot
Unconjugated
GRIN2B
Liquid
GRIN2B
Phosphopeptide corresponding to amino acid residues surrounding the phosphotyrosine 1252 of the NR2B subunit of the rat NMDA receptor.
Affinity chromatography
RUO
Antibody
Polyclonal
Bovine, Canine, Chicken, Human, Mouse, Rat, Zebrafish
Documents
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