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Phospho-p38 MAPK alpha (Thr180, Tyr182), Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112741

Catalog No. 01-674-866

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

p38 MAPK cascade regulates a variety of cellular responses to stress, inflammation and other signals. p38 MAPK is relatively inactive in the non-phosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motifs. There are four isoforms of p38 MAPK, a, b, g and d, which differ in their tissue expression and affinity for upstream activators and downstream effectors. When cells are exposed to tumor necrosis factor-a, interleukin-1, heat shock, or other activating stimuli, activation of MAPK kinase-3 and -6 occurs by phosphorylation. Activated MAPK kinase-3/6 phosphorylate each residue of Thr180 and Tyr182 in p38 MAPK. Phospho-p38 MAPK activates ATF-2, CHOP-1, MEF-2 and other transcription factors through phosphorylation.

In Western blot, immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide; immunolabeling can be completely eliminated by treatment with lambda-phosphatase. A suggested positive control for this product is C-6 glioma cell lysate.
Specifications

Specifications

Phospho-p38 MAPK alpha (Thr180, Tyr182)
Polyclonal
HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Q16539, P47811, P70618
Map kinase
Rabbit
IgG
10 Miniblots
-20° C, Avoid Freeze/Thaw Cycles, Avoid Freeze/Thaw Cycles
Primary
1432, 26416, 81649
Dot Blot, Western Blot
Unconjugated
MAPK14
Liquid
MAPK14
Synthetic phosphopeptide corresponding to amino acid residues surrounding phospho Thr180/Tyr182 of p38
Affinity chromatography
RUO
Antibody
Polyclonal
Human, Murine, Rat
Documents
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