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anti-Phospho-p53 pSer15 Clone: 14H61L24, Invitrogen™

Phospho-p53 pSer15 Monoclonal antibody 700439 from Thermo Scientific™ Pierce™ specifically detects Phospho-p53 pSer15 in Human samples, and it is validated for IF, ICC, FACS, ChIP and FRET

Manufacturer:  Invitrogen 700439

Encompass

Catalog No. 70-043-9


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Description

Description

The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. Activation of p53 can lead to either cell cycle arrest and DNA repair, or apoptosis. p53 acetylation at Lys382 is required for recruitment of p300 to the p21 promoter, and is mediated by p300 and CBP acetyltransferases. Acetylation appears to play a positive role in the accumulation of p53 protein in stress responses, and inhibition of deacetylation stabilizes p53.

700439 detects Phospho-p53 pSer15 in Human samples. 700439 has been successfully used in IF, ICC, FACS, ChIP and FRET procedures. The immunogen for 700439 is a peptide corresponding to amino acids 9-19 of P04637.

Applications:

Chromatin Immunoprecipitation, FACS, Immunocytochemistry, Immunofluorescence

Specifications

Specifications

Phospho-p53 pSer15
Unconjugated
P04637
Rabbit
IgG
Store at 2 to 8°C for up to 1 month. For long term storage, store at -20°C.
Monoclonal
Human
14H61L24
100μg of Protein A antibody in PBS with 0.09% sodium azide;
Purified
A peptide corresponding to amino acids 9-19 of P04637.
Protein A
Primary
7157
SDS
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