Phospho-PAK1/2/3 (Thr402) Rabbit anti-Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA14636
This antibody is predicted to react with bovine, canine, human and mouse based on 100% sequence homology. This antibody is specific for the ~68 kDa to ~70 kDa PAK phosphorylated at Thr402. Immunolabeling can be blocked by lambda-phosphatase treatment.In mammals, there are several identified isoforms of p21-Activated Protein Kinases or PAKs: alpha-PAK (also known as PAK-1) and beta-PAK (also known as PAK-3) are mostly brain-specific, while gamma-PAK (also known as PAK-2) is expressed ubiquitously (Jakobi et al., 2003). Mutations of the gene coding for PAK-3 are associated wit X-linked mental retardation and recent work indicates that PAK-3 is a key regulator of synapse formation and plasticity in the hippocampus (Boda et al., 2004). PAK-3 is thought to play a key role in regulation of cell shape and motility as well as cell death (Jakobi et al., 2003; Walter et al., 1998). Autophosphorylation of Thr402 in the protein has been found to be essential for activation of PAK (Jakobi et al., 2000).
|0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5|
|P35465, Q62829, Q64303|
|Pak1, Pak2, Pak3, p21-Activated Protein Kinase-1, 2, 3, Serine/threonine-protein kinase PAK 1, Alpha-PAK, p21-activated kinase 1, PAK-1, p65-PAK, Serine/threonine-protein kinase PAK 2, Gamma-PAK, PAK65, S6/H4 kinase, p21-activated kinase 2, PAK-2, p58, PAK-2p27, PAK-2p34, p34, C-t-PAK2, Serine/threonine-protein kinase PAK 3, Beta-PAK, Oligophrenin-3, p21-activated kinase 3, PAK-3, OPHN3|
|-20° C, Avoid Freeze/Thaw Cycles|
|29431, 29432, 29433|
|PAK1, PAK2, PAK3|
|Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr402 of rat PAK1-3 conjugated to KLH|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok