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Phospho-Paxillin (Tyr118) Rabbit anti-Canine, Chicken, Human, Mouse, Non-human primate, Rat, Zebrafish, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523327

Catalog No. PIPA523327


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Description

Description

Paxillin is a protein with four LIM domains, a proline-rich domain containing a consensus SH3-binding site, and three potential SH2-binding sites. It acts as an ERK-regulated scaffold that coordinates FAK and Rac activation in epithelial morphogenesis. Paxillin is a novel vinculin-binding protein present in focal adhesions and its isoforms in monocyte and cancer cells are known to have different binding properties to focal adhesion proteins. Paxillin binds to schwannomin and regulates its density-dependent localization and effect on cell morphology. Phosphorylation of Paxillin by JNK is known to regulate cell migration. The human Paxillin gene is localized in the chromosomal region 12q24.31.
Specifications

Specifications

Phospho-Paxillin (Tyr118)
Polyclonal
Unconjugated
PXN
Liquid
PXN, pxna
Synthetic peptide (111 VGEEEHV(Y)SFPNKQK 125) of Phospho-Paxillin pTyr118 protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Canine, Chicken, Human, Mouse, Non-human primate, Rat, Zebrafish
Western Blot
0.2 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
P49024, P49023, Q8VI36, Q66H76
hCG_1778014
Rabbit
IgG
20 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
19303, 360820, 395832, 399546, 486299, 5829
Documents
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