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Phospho-VPS34 (Ser164) Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA512829

Catalog No. PIPA512829


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Description

Description

This antibody is predicted to react with mouse, porcine and rat based on sequence homology.

PI3KC3 is a catalytic subunit of the PI3K complex involved in the transport of lysosomal enzyme precursors to lysosomes. This enzyme acts catalytically to convert 1-phosphatidyl-1D-myo-inositol to 1-phosphatidyl-1D-myo-inositol 3-phosphate. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The regulation of the Beclin 1-PI3KC3 complex lipid kinase activity is a critical element in the autophagy signaling pathway.
Specifications

Specifications

Phospho-VPS34 (Ser164)
Polyclonal
PBS with 0.09% sodium azide
Q8NEB9
Phosphatidylinositol 3-kinase catalytic subunit type 3; PtdIns-3-kinase type 3; PI3-kinase type 3; PI3K type 3; Phosphoinositide-3-kinase class 3; Phosphatidylinositol 3-kinase p100 subunit; vps34
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
5289
Dot Blot
Unconjugated
PIK3C3
Liquid
PIK3C3
KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S164 of human PI3KC3
Antigen Affinity Chromatography, Protein A
RUO
Antibody
Polyclonal
Human
Documents
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