Phospho-PKC alpha (Thr638) Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen 44962G
DescriptionProtein kinase C is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
|Phospho-PKC alpha (Thr638)|
|Dulbecco′s PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide; pH 7.3|
|P17252, P20444, P05696|
|EC 18.104.22.168, KPCA, PKC III, PKC-A, PKC-III, PKC-alpha, PRKACA, PRKCA, Protein kinase C, alpha type, kinase PKC-alpha|
|18750, 24680, 5578|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human PKC that contains threonine 638. The sequence is conserved in mouse and rat.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
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