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Phospho-PKC delta (Ser664) Rabbit anti-Human, Rat, Polyclonal, Invitrogen™ Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen 44976G

Catalog No. 44-976-G


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Description

Description

Members of the Protein kinase C (PKC) family of serine/threonine protein kinases are grouped by their activation mechanism. Classical or conventional PKCs (PKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol. The Ca2+ insensitive novel PKCs (PKCs epsilon-, delta-, theta- and eta) are also activated by diacylglycerol and phosphatidylserine. The atypical PKCs (PKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbolesters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain via a hinge region. PKCs are involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP.
Specifications

Specifications

Phospho-PKC delta (Ser664)
Polyclonal
Dulbecco′s PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide; pH 7.3
Q05655, P09215
EC 2.7.11.13, KPCD, PKC-delta, PRKCD, kinase PKC-delta, nPKC-delta
Rabbit
IgG
100 μL
-20°C
Primary
170538, 5580
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
PRKCD
Liquid
PRKCD
The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human PKCd that contains serine 664.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Rat
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