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Phospho-PLK1 (Ser482, Ser486, Ser490) Rabbit anti-Xenopus laevis, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA14637

Catalog No. PA14637


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Description

Description

This antibody is predicted to react with rat, mouse, human and zebrafish based on 100% sequence homology. This antibody is specific for the ~120 kDa PLKK protein phosphorylated at Ser482,486,490 in Western blots of Xenopus lysates.

Considerable evidence indicates that a Polo-Like Kinase (PLK) plays an important role in cell cycle regulation. PLK is also required for bipolar spindle formation, activation of the anaphase-promoting complex/cyclosome, and cytokinesis. Recent work led to the identification of a PLKK that is thought to be responsible for activation of PLK. Recent work (Erikson, et al., 2004) has shown that PLKK is in turn activated by phosphorylation at three sites (Ser482, Ser486 and Ser490). Thus activation of PLK is thought to involve a kinase cascade involving the phosphorylation of Ser482,486,490 in PLKK.
Specifications

Specifications

Phospho-PLK1 (Ser482, Ser486, Ser490)
Polyclonal
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
P70032
phospho-polo-like-kinase (Ser482,486,490)
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
380481
Western Blot
Unconjugated
plk1.S
Liquid
plk1.S
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser482/486/490 of Xenopus PLK1 conjugated to KLH
Affinity chromatography
RUO
Antibody
Polyclonal
Xenopus laevis
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