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Phospho-KV3.1 (Ser503) Rabbit anti-Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA14638

Catalog No. PA14638


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Description

Description

This antibody is specific for the ~100 kDa Voltage Gated Potassium Channel KV3 1-subunit protein phosphorylated at Ser503 in Western blots of rat brain extracts.

Voltage-gated K+ channels are important determits of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al , 1995 Pongs, 1999 Blaine and Ribera, 1998 Burger and Ribera, 1996). The Kv3 1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al , 1999). Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al , 2004).
Specifications

Specifications

Phospho-KV3.1 (Ser503)
Polyclonal
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
P15388, P25122
FLJ41162, FLJ42249, FLJ43491, KV3.1, KV4, MGC129855, NGK2
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
16502, 25327
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Western Blot
Unconjugated
Kcnc1
Liquid
KCNC1
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser503 of rat KCNC1 conjugated to KLH
Affinity chromatography
RUO
Antibody
Polyclonal
Mouse, Rat
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