Phospho-KV3.1 (Ser503) Rabbit anti-Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA14638
This antibody is specific for the ~100 kDa Voltage Gated Potassium Channel KV3 1-subunit protein phosphorylated at Ser503 in Western blots of rat brain extracts.Voltage-gated K+ channels are important determits of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al , 1995 Pongs, 1999 Blaine and Ribera, 1998 Burger and Ribera, 1996). The Kv3 1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al , 1999). Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al , 2004).
|0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5|
|FLJ41162, FLJ42249, FLJ43491, KV3.1, KV4, MGC129855, NGK2|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Western Blot|
|Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser503 of rat KCNC1 conjugated to KLH|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok