Phospho-Progesterone Receptor (Ser294) Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA125647
PA1-25647 detects Progesterone Receptor (phospho S294) from human samples. PA1-25647 has been successfully used in Western blot and dot blot procedures. The PA1-25647 immunogen is a synthetic phosphopeptide corresponding to a portion of of human Progesterone Receptor containing serine 294. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze/thaw cycles.The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintece of pregcy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintece of the endometrium, maintece of pregcy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.
|Phospho-Progesterone Receptor (Ser294)|
|HEPES buffered saline with 100μg/mL BSA, 50% glycerol and no preservative|
|PR, NR3C3, PGR|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Dot Blot, Western Blot|
|Synthetic phosphopeptide corresponding to a portion of of human Progesterone Receptor containing serine 294.|
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