Phospho-RAD17 (Ser645) Rabbit anti-Human, Mouse, Non-human primate, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523330
DescriptionRad17, also known as ft.cell cycle checkpoint protein RAD17, ft. is a nuclear protein belonging to the Rad17/RAD24 family and necessary for sustained cell growth, maintece of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Rad17 is known to have a weak ATPase activity and is required for binding to chromatin and also participates in the recruitment of the RAD1-RAD9-HUS1 complex onto chromatin, and in CHEK1 activation. It may also serve as a sensor of DNA replication progression, and may be involved in homologous recombination. Rad17 is a part of a DNA-binding complex containing RFC2, RFC3, RFC4 and RFC5. Four isoforms have been reported by X-ray irradiation. Overexpression of this protein is seen in various cancer cell lines and in colon carcinoma.
|Synthetic peptide (638 SASELPA(S)QPQPFS 651) of Phospho-RAD17 pSer645 protein.|
|Antigen affinity chromatography|
|Human, Mouse, Non-human primate|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.05% BSA and 0.05% sodium azide|
|CCYC, HRAD17, R24L, RAD17SP, RAD24, RAD1 homolog, RF-C activator 1 homolog, RF-C/activator 1 homolog, Rad17-like protein, cell cycle checkpoint protein (RAD17), cell cycle checkpoint protein RAD17|
|-20° C, Avoid Freeze/Thaw Cycles|
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