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Phospho-c-Raf (Ser642) Rabbit anti-Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA14640

Catalog No. PA14640


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Description

Description

This antibody is predicted to react with bovine, canine, chicken, human, mouse and non-human primate based on 100% sequence homology. This antibody is specific for the ~74 kDa Raf-1 protein phosphorylated at Ser642.

The Ras pathway is a critical signal transduction cascade involved in regulating cellular proliferation, differentiation, survival, and oncogenic transformation. Members of the Raf serine/threonine kinase family are key intermediates in this cascade, functioning to relay signals from activated Ras to the downstream protein kinases MEK and ERK (Marshall, 1996). Previous studies have shown that phosphorylation is required for Raf-1activation (Dhillon and Kolch, 2002; Chong et al., 2003). Recent work has demonstrated that phosphorylation also regulates the downregulation of Raf (Dougherty et al., 2005) with two sites participating Ser301 and Ser642.
Specifications

Specifications

Phospho-c-Raf (Ser642)
Polyclonal
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
P11345
Craf 1 transforming gene, Craf1 transforming gene, Murine sarcoma 3611 oncogene 1, Raf proto oncogene serine/threonine protein kinase, vraf1 murine le
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
24703
Western Blot
Unconjugated
Raf1
Liquid
RAF1
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser642 of rat RAF1 conjugated to KLH
Affinity chromatography
RUO
Antibody
Polyclonal
Rat
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