Phospho-Rb (Ser780) Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA512681
This antibody is predicted to react with mouse and rat based on sequence homology.RB1 likely acts as a regulator of other genes. It forms a complex with adenovirus E1A and with SV40 large T antigen, acts as a tumor suppressor, and may bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. RB1 is a potent inhibitor of E2F-mediated trans-activation, and also recruits and targets histone methyltransferase SUV39H1 leading to epigenetic transcriptional repression. This protein inhibits the intrinsic kinase activity of TAF1. Defects in RB1 are the cause of childhood cancer retinoblastoma (RB), a congenital maligt tumor that arises from the nuclear layers of the retina. Defects in RB1 are also a cause of bladder cancer and osteogenic sarcoma.
|PBS with 0.09% sodium azide|
|Retinoblastoma-associated protein; PP110; P105-RB; RB; RB1;|
|-20° C, Avoid Freeze/Thaw Cycles|
|Dot Blot, Immunohistochemistry|
|KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S780 of human Rb|
|Antigen Affinity Chromatography, Protein A|
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