Phospho-POLR2A (Ser5), clone: 8A7, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA15875
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.MA1-5875 detects Phospho-RNA polymerase II CTD in human and S. cerevisiae samples.MA1-5875 has been successfully used in Western blot, ELISA and immunofluorescence procedures.The MA1-5875 immunogen is synthetic peptide, YSPTSpPS (human).
|PBS with 0.1% sodium azide|
|Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|ELISA, Immunocytochemistry, Immunofluorescence, Western Blot|
|Synthetic peptide: YSPTSpPS (Human) from Sp2/0 Ag.14 cells|