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Phospho-SMAD2 (Ser465, Ser467) Rabbit anti-Human, Invitrogen™

Rabbit Recombinant Polyclonal Antibody

Manufacturer:  Invitrogen 710612

Catalog No. PI710612


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Description

Description

This antibody is predicted to react with mouse, bovine, zebrafish and drosophila based on sequence homology. Recombit rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombit monoclonal antibodies, providing the best of both worlds – the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombit antibody. While functionally the same as a polyclonal antibody – recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets – a recombit rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.

SMAD2 (MADH2, MAD2) regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. SMAD2 interacts with the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation into the nucleus is a central event in TGF beta signaling. Phosphorylation of threonine 8 in the calmodulin-binding region of the MH1 domain by extracellular signal regulated kinase 1 (ERK1) enhances SMAD2 transcriptional activity, which is negatively regulated by calmodulin. In response to the TGF-beta signal, SMAD2 is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. SMAD2 can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants encoding the SMAD2 protein have been observed.
Specifications

Specifications

Phospho-SMAD2 (Ser465, Ser467)
Recombinant Polyclonal
Unconjugated
SMAD2
Liquid
SMAD2
Synthetic peptide corresponding to human SMAD2, aa 461-467, phosphorylated at Serine 465/467
Protein A
RUO
Antibody
Oligoclonal
Human
Immunocytochemistry, Immunofluorescence, Western Blot
0.5 mg/mL
PBS with 0.09% sodium azide
Q15796
JV18, JV18-1, MADH2, MADR2, MGC22139, MGC34440, hMAD-2, hSMAD2, pSMAD2
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
4087
Documents
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