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Phospho-SMAD3 (Ser213) Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA512694

Catalog No. PIPA512694


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Description

Description

This antibody is predicted to react with chicken, mouse, porcine and rat based on sequence homology.

SMAD3, a receptor regulated SMAD (R-SMAD) is a transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is estimated to account for at least 80% of all TGF-beta-mediated response. Activated type I receptor phosphorylates receptor-activated SMADS (RSMADS) at their c-terminal two extreme serines in the SSXS motif. The phosphorylated R-SMAD translocate into nucleus, where they regulate transcription of target genes. SMAD3 signal transduction appears to be important in the rgulation of muscle-specific genes. Loss of SMAD3 is a feature of pediatric T-cell lymphoblastic leukemia, while upregulation of SMAD3 may be responsible for TGFB hyperresponsiveness observed in scleroderma.
Specifications

Specifications

Phospho-SMAD3 (Ser213)
Polyclonal
Unconjugated
SMAD3
Liquid
SMAD3
KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S213 of human SMAD3
Antigen Affinity Chromatography, Protein A
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
0.4 mg/mL
PBS with 0.09% sodium azide
P84022
Mothers against decapentaplegic homolog 3; SMAD 3; Mothers against DPP homolog 3; Mad3; hMAD-3; JV15-2; hSMAD3; SMAD3; MADH3;
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
4088
Documents
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