Phospho-Synapsin 1 (Ser9) Rabbit anti-Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA14603
This antibody is predicted to react with bovine, human, mouse, Xenopus and zebrafish based on 100% sequence homology. In Western blot, this antibody detects an ~78 kDa protein representing Phospho-Ser9 Synapsin protein. It also weakly labels the ~ 55 kDa Synapsin II protein which has a similar phosphorylation site to that of SER9 on Synapsin I.SYN1 (synapsin 1) is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins that associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains and are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. Synapsin 1 plays a role in regulation of axonogenesis and synaptogenesis. It serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
|Phospho-Synapsin 1 (Ser9)|
|0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5|
|Brain protein 4.1|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry, Western Blot|
|Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser9 of rat SYN1 conjugated to KLH|
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