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Phospho-TAOK2 (Ser181) Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA14643

Catalog No. PA14643


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Description

Description

This antibody is predicted to react with zebrafish, Xenopus, finch and canine based on 100% sequence homology. This antibody is specific for the ~120 kDa TAO2 phosphorylated at Ser181 in Western blots of rat hippocampal lysate.

In vitro, TAO (thousand and one amino acid) protein kinase 2 (TAO2) activates MAP/ERK kinases (MEK ) 3, 4, and 6 toward their substrates p38 MAP kinase JNK/SAPK (Chen et al., 1999; Chen and Cobb, 2001). This and more recent work has led to the proposal that the TAO protein kinases play an essential role in signaling from physiological agonist to the stress -responsive p38 MAPK (Chen et al., 2003). Autophosphorylation of TAO may play a role in the mechanism of TAO activation. The MEK binding domain of TAO is autophosphorylated on both serine and threonine residues and Ser181 is located within this domain.
Specifications

Specifications

Phospho-TAOK2 (Ser181)
Polyclonal
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Q9UL54, Q6ZQ29, Q9JLS3
thousand and one amino acid protein kinase 2
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
381921, 64666, 9344
Western Blot
Unconjugated
TAOK2
Liquid
TAOK2
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser181 of human TAOK2 conjugated to KLH
Affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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