Phospho-TAOK2 (Ser181) Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA14643
This antibody is predicted to react with zebrafish, Xenopus, finch and canine based on 100% sequence homology. This antibody is specific for the ~120 kDa TAO2 phosphorylated at Ser181 in Western blots of rat hippocampal lysate.In vitro, TAO (thousand and one amino acid) protein kinase 2 (TAO2) activates MAP/ERK kinases (MEK ) 3, 4, and 6 toward their substrates p38 MAP kinase JNK/SAPK (Chen et al., 1999; Chen and Cobb, 2001). This and more recent work has led to the proposal that the TAO protein kinases play an essential role in signaling from physiological agonist to the stress -responsive p38 MAPK (Chen et al., 2003). Autophosphorylation of TAO may play a role in the mechanism of TAO activation. The MEK binding domain of TAO is autophosphorylated on both serine and threonine residues and Ser181 is located within this domain.
|0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5|
|Q9UL54, Q6ZQ29, Q9JLS3|
|thousand and one amino acid protein kinase 2|
|-20° C, Avoid Freeze/Thaw Cycles|
|381921, 64666, 9344|
|Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser181 of human TAOK2 conjugated to KLH|
|Human, Mouse, Rat|
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