Phospho-TSC1 (Ser505) Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA512900
This antibody is predicted to react with mouse based on sequence homology.TSC1 is implicated as a tumor suppressor, and may have a function in vesicular transport. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Defects in TSC1 are the cause of tuberous sclerosis complex (TSC). The molecular basis of TSC is a functional impairement of the hamartin-tuberin complex. TSC is an autosomal domit multi-system disorder that affects especially the brain, kidneys, heart, and skin. Defects in TSC1 may be a cause of focal cortical dysplasia of Taylor balloon cell type (FCDBC). FCDBC is a subtype of cortical displasias linked to chronic intractable epilepsy. Cortical dysplasias display a broad spectrum of structural changes, which appear to result from changes in proliferation, migration, differentiation, and apoptosis of neuronal precursors and neurons during cortical development.
|PBS with 0.09% sodium azide|
|Hamartin; Tuberous sclerosis 1 protein; TSC1; KIAA0243; TSC|
|-20° C, Avoid Freeze/Thaw Cycles|
|KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S505 of human TSC1|
|Antigen Affinity Chromatography, Protein A|
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