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Phospho-TSC1 (Ser505) Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA512900

Catalog No. PIPA512900


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Description

Description

This antibody is predicted to react with mouse based on sequence homology.

TSC1 is implicated as a tumor suppressor, and may have a function in vesicular transport. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Defects in TSC1 are the cause of tuberous sclerosis complex (TSC). The molecular basis of TSC is a functional impairement of the hamartin-tuberin complex. TSC is an autosomal domit multi-system disorder that affects especially the brain, kidneys, heart, and skin. Defects in TSC1 may be a cause of focal cortical dysplasia of Taylor balloon cell type (FCDBC). FCDBC is a subtype of cortical displasias linked to chronic intractable epilepsy. Cortical dysplasias display a broad spectrum of structural changes, which appear to result from changes in proliferation, migration, differentiation, and apoptosis of neuronal precursors and neurons during cortical development.
Specifications

Specifications

Phospho-TSC1 (Ser505)
Polyclonal
PBS with 0.09% sodium azide
Q92574
Hamartin; Tuberous sclerosis 1 protein; TSC1; KIAA0243; TSC
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
7248
Dot Blot
Unconjugated
TSC1
Liquid
TSC1
KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S505 of human TSC1
Antigen Affinity Chromatography, Protein A
RUO
Antibody
Polyclonal
Human
Documents
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