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Phospho-TSC2 (Ser1420) Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA512909

Catalog No. PIPA512909


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Description

Description

TSC2 (Tuberin, Tuberous sclerosis complex, TSC Complex Subunit 2), is implicated as a tumor suppressor and may function in vesicular transport, play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. TSC2 associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Phosphorylation of tuberin on Ser 939 and Thr 1462 regulates its interaction with hamartin, and is stimulated by various growth factors through the phosphoinositide 3-kinase/Akt pathway. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking. TSC2 specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors and are involved in diseases such as lymphangioleiomyomatosis and TSC2 angiomyolipoma. Alternative splicing results in transcript variants of three different isoforms of TSC2.
Specifications

Specifications

Phospho-TSC2 (Ser1420)
Polyclonal
PBS with 0.09% sodium azide
P49815
Tuberin; Tuberous sclerosis 2 protein; TSC2; TSC4
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
7249
Dot Blot, Immunocytochemistry, Immunofluorescence
Unconjugated
TSC2
Liquid
TSC2
KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1420 of human TSC2
Antigen Affinity Chromatography, Protein A
RUO
Antibody
Polyclonal
Human
Documents
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