Phospho-Tyrosine Hydroxylase (Ser40) Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA112746
Tyrosine Hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines Dopamine and Norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000; Salvatore et al., 2001; Dunkley et al., 2004). The activity of TH is also regulated by phosphorylation (Haycock et al., 1982; Haycock et al., 1992; Jedynak et al., 2002). Phospho-specific antibodies for the phosphorylation sites on TH can be used to great effect in studying this regulation and in identifying the cells in which TH phosphorylation occurs.A suggested positive control for this product is PC-12 cell lysate stimulated with okadaic acid.
|Phospho-Tyrosine Hydroxylase (Ser40)|
|HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5|
|P07101, P24529, P04177|
|Synthetic phosphopeptide corresponding to residues surrounding the phospho-Ser40 site of rat tyrosine hydroxylase.|
|Human, Mouse, Rat|
|Dot Blot, Immunofluorescence, Immunohistochemistry (Frozen), Western Blot|
|TH, TYH antibody, Tyrosine 3 monooxygenase antibody|
|21823, 25085, 7054|
|-20° C, Avoid Freeze/Thaw Cycles|
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