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Phospho-Tyrosine Hydroxylase (Ser40) Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112746

Catalog No. 01-674-871


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Description

Description

Tyrosine Hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines Dopamine and Norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000; Salvatore et al., 2001; Dunkley et al., 2004). The activity of TH is also regulated by phosphorylation (Haycock et al., 1982; Haycock et al., 1992; Jedynak et al., 2002). Phospho-specific antibodies for the phosphorylation sites on TH can be used to great effect in studying this regulation and in identifying the cells in which TH phosphorylation occurs.

A suggested positive control for this product is PC-12 cell lysate stimulated with okadaic acid.
Specifications

Specifications

Phospho-Tyrosine Hydroxylase (Ser40)
Polyclonal
HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
P07101, P24529, P04177
TH, TYH antibody, Tyrosine 3 monooxygenase antibody
Rabbit
IgG
10 Miniblots
-20° C, Avoid Freeze/Thaw Cycles
Primary
21823, 25085, 7054
Dot Blot, Immunofluorescence, Immunohistochemistry (Frozen), Western Blot
Unconjugated
TH
Liquid
TH
Synthetic phosphopeptide corresponding to residues surrounding the phospho-Ser40 site of rat tyrosine hydroxylase.
Affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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