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Phospho-Zap-70 (Tyr315, Tyr319), Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA125547

Catalog No. PIPA125547

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

PA1-25547 detects ZAP70 (phospho Y315 + Y319) from human samples. PA1-25547 is expected to cross react with mouse due to sequence homology.PA1-25547 has been successfully used in Western blot procedures.The PA1-25547 immunogen is a synthetic phosphopeptide corresponding to a portion of human ZAP70 that contains tyrosines 315 and 319.
Specifications

Specifications

Phospho-ZAP70 pTyr315+319
Polyclonal
Dulbecco's PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide; pH 7.3
P43403, P43404
FLJ17670, FLJ17679, SRK, STD, TZK, ZAP-70
Rabbit
IgG
50μL
Store at -20°C
Primary
7535
Western Blot
Unconjugated
ZAP70
Purified
ZAP70
Synthetic phosphopeptide corresponding to a portion of human ZAP70 that contains tyrosines 315 and 319.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Murine
Documents
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