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Phospholipase Cg (pY783) Mouse, Unlabeled, Clone: 27, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 612465

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Catalog No. BDB612465


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Description

Description

The Phospholipase C (PLC) isozymes hydrolyze phosphatidyl inositol phosphate to inositol triphosphate and diacylglycerol. The former causes release of calcium from the endoplasmic reticulum, while the latter is an activator of Protein Kinase C. Within the PLC family, PLCγ is the only member that contains SH2 and SH3 domains. These domains enable it to interact with receptor tyrosine kinases and become enzymatically activated via phosphorylation. It exists as two isoforms: 1) PLCγ1, which is ubiquitously expressed, and 2) PLCγ2, found primarily in the lymphoid system. PLCγ is essential for growth factor-induced cell motility and mitogenesis. PLCγ1-null mice exhibit retarded embryonic growth and lethality in midgestation. In addition, PDGF stimulation leads to phosphorylation of PLCγ at Tyr 783, and activation of hydrolyzing activity. Overexpression of PLCγ is evident in several forms of cancer and it has been identified as a key mediator of PDGF-dependent cellular transformation. Thus, regulation of PLCγ activity by growth factors is involved in cell growth and transformation.

Western Blotting

Specifications

Specifications

Phospholipase Cg (pY783)
27
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
PLCγ (pY783)
Affinity Purified
Human Phosphorylated PLCγ1 Peptide
150μg
Cell Biology
Primary
Human, Murine, Rat
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