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Phosphotyrosine Mouse anti-Chemical, HRP, Clone: pY20, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112445

Catalog No. 01-674-312


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Description

Description

A suggested positive control for this product is A431 cells stimulated with EGF.

The role of tyrosine phosphorylation in transduction of the mitogenic signal from transmembrane receptors and in transformation by oncogene tyrosine kinases has been the subject of intense investigation for several years. While the phosphorylation of specific tyrosine residues has been shown to be a primary mechanism of signal transduction during normal mitogenesis, cell cycle progression and oncogenic transformation, its role in other areas such as differentiation and gap junction communication, is a matter of active and ongoing research. Antibodies that specifically recognize phosphorylated tyrosine residues have proved to be invaluable to the study of tyrosine -phosphorylated proteins and the biochemical pathways in which they function. The fluorescein (FITC) conjugate of clone PY20 anti-phosphotyrosine is especially useful for the detection of these P-Tyr proteins in immunohistochemical and immunocytochemical protocols in situations wherein the use of a secondary antibody would complicate detection of the protein(s) of interest.
Specifications

Specifications

Phosphotyrosine
Monoclonal
HRP
Liquid
Mouse
IgG2b
50 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
Chemical
ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
PY20
PBS with 50% glycerol and no preservative; pH 7.5
pTyr; pY; Phosphotyrosine
Phosphotyrosine coupled to carrier protein.
Purified
RUO
Antibody
Monoclonal
Documents
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