PIK3R1 Rabbit anti-Human, Non-human primate, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA129194
PA1-29195 detects Phospholipase C1 from bovine samples. PA1-29195 has been successfully used in immunoprecipitation, Western blot applications. The PA1-29195 immunogen is: Synthetic peptide corresponding to the C-terminus of Bovine PLCgamma1 proteinPhosphatidylinositol 3-kinase (PIK3) is a signaling protein that phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. Signaling is initiated when upstream tyrosine kinase receptors or G protein coupled receptors are bound by their ligands. It binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. During insulin stimulation, it also binds to IRS-1. Mutations in the gene can result in Agammaglobulinemia 7, SHORT syndrome, or Immunodeficiency 36.
|4° C, do not freeze|
|PBS with 0.2% BSA and 0.1% sodium azide; pH 7.4|
|Synthetic peptide from the C terminal SH2 domain of p85 alpha subunit of phosphatidylinositol (PI) 3-kinase.|
|Human, Non-human Primate, Rat|