PIK3C2A Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA528071
PA5-28071 targets PI3 kinase C2 alpha in IF, IHC-P, and WB applications and shows reactivity with Human samples. The PA5-28071 immunogen is synthetic peptide corresponding to a region within amino acids 1624 and 1686 of Human PI3 kinase C2 alpha. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to omolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.
|Synthetic peptide corresponding to a region within amino acids 1624 and 1686 of Human PI3 kinase C2 alpha|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7|
|CPK, PI3-K-C2(ALPHA), PI3-K-C2A, C2-containing phosphatidylinositol kinase, PI3K-C2-alpha, PI3K-C2alpha, phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha, phosphoinositide 3-kinase-C2-alpha, ptdIns-3-kinase C2 subunit alpha|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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