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PI3-Kinase C2β Mouse anti-Human, Unlabeled, Clone: 22, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611343

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Catalog No. BDB611343


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Description

Description

Phosphatidylinositol (PtdIns) (3) kinase phosphorylates the D-3 position of the inositolring of PtdIns, producing PtdIns(3)P, PtdIns(3,4)P2, and PtdIns(3,4,5)P3. PI3-kinase is a heterodimer of an 85kDa regulatory subunit (p85) and a 110kDa catalytic subunit (p110). However, it is only one member of a larger family of proteins with similarity to the p110 subunit. These different PI3-kinase isoforms have been divided into three classes. Class I consists of p110α and p110-» which bind the p85 subunit and associate with receptor tyrosine kinases. Class II includes 68D and cpk from Drosophila, p170 and cpk-m from mouse, and C2α, C2-» (HsC2), and C2γ from human. These proteins phosphorylate PtdIns and PtdIns(4)P, but not PtdIns(4,5)P2, and each contain a C-terminal C2 domain that may negatively regulate the catalytic domain. Class III members only phosphorylate PtdIns to PtdIns(3)P and include the S. cerevisiae Vps34p and its human homologs. In humans, the class II PI3-kinases C2α and C2-» have similar catalytic, PI kinase, and C2 domains. However they differ in their N-terminal regions. In addition, C2β has no cation specificity, while C2α prefers Mg2+-ATP for optimal phosphorylation.

Host Species: Mouse
Clone: 22
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human PI3-Kinase C2β aa. 16-209
Formula Weight [Chemical]: 165kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

PI3-Kinase C2β
22
Unconjugated
Affinity Purified
Human PI3-Kinase C2β aa. 16-209
150μg
Cell Biology
Primary
Human
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Documents
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