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PI3K p85 alpha Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA515257

Catalog No. PIPA515257

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

This antibody is predicted to react with bovine, mouse and rat based on sequence homology.

Phosphatidylinositol 3-kinase (PIK3) is a signaling protein that phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. Signaling is initiated when upstream tyrosine kinase receptors or G protein coupled receptors are bound by their ligands. It binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. During insulin stimulation, it also binds to IRS-1. Mutations in the gene can result in Agammaglobulinemia 7, SHORT syndrome, or Immunodeficiency 36.
Specifications

Specifications

PI3K p85 alpha
Polyclonal
PBS with 0.09% sodium azide
P27986
Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase p85-subunit alpha; PtdIns-3-kinase p85-alpha; PI3K; PIK3R1; GRB1;
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
5295
Immunohistochemistry, Western Blot
Unconjugated
PIK3R1
Liquid
PIK3R1
KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PI3KR1
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human
Documents
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