PIAS2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520952
A suggested positive control is rat brain tissue lysate. PA5-20952 can be used with blocking peptide PEP-1066.The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS2. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS2 binds specifically to STAT4 following IL-12 stimulation and inhibits STAT4-mediated gene activation in human T cells. PIAS2 is a potent transcriptional activator of Bcl-2, but together with Bcl-6 can suppress the expression of Bcl-2.
|An 18 amino acid peptide near the amino terminus of human PIAS2.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|O75928, Q8C5D8, Q6AZ28|
|ARIP3, DIP, MIZ, MIZ1, PIASX, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4; DAB2-interacting protein; E3 SUMO-protein ligase PIAS2; androgen receptor-interacting protein 3; msx-interacting zinc finger protein; protein inhibitor of activated STAT X; zinc finger, MIZ-type containing 4|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|17344, 83422, 9063|
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