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PIAS3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520953

Catalog No. PIPA520953


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Description

Description

A suggested positive control is K562 cell lysate. PA5-20953 can be used with blocking peptide PEP-1067.

The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS3. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS3 binds specifically to STAT3 following the stimulation of STAT3. Increased expression of PIAS3 has been observed in several human cancers, including lung, breast, and brain tumors, but not in anaplastic lymphoma kinase-positive T/null-cell lymphomas, indicating that PIAS3 plays multiple roles in different tissue and cell types.
Specifications

Specifications

PIAS3
Polyclonal
Unconjugated
PIAS3
Liquid
PIAS3
a 12 amino acid peptide near the carboxy terminus of human PIAS3.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9Y6X2, O54714, O70260
ZMIZ5; E3 SUMO-protein ligase PIAS3; protein inhibitor of activated STAT protein 3; zinc finger, MIZ-type containing 5
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
10401, 229615, 83614
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